In preclinical pharmacology and toxicology, surgical models must be both precise and reliable — especially when the goal is to study hepatic metabolism, biliary excretion, or mass balance.  Rodent bile duct cannulation (BDC) is one such model that demands a high level of surgical skill, rigorous technique, and unwavering attention to animal welfare.

At Preclinical Research Associates (PRA), we specialize in performing these complex surgeries onsite at your facility, helping research teams eliminate variability, reduce animal stress, and generate cleaner, more reproducible data.

Why Bile Duct Cannulation?

Bile duct cannulation in rats and mice is a gold standard technique for:

– Measuring biliary excretion** of drugs and metabolites

– Performing mass balance and ADME studies**

– Evaluating enterohepatic recirculation**

– Enhancing pharmacokinetic data** with dual sampling options (bile and plasma)

With this model, researchers can extract more meaningful data from fewer animals — making it both scientifically robust and ethically responsible.

The Challenge: Technical Complexity

BDC surgery is highly specialized and requires:

– Microsurgical precision

– Anesthesia and intraoperative monitoring expertise

– Customized equipment and catheter placement techniques

– Close post-operative observation and care

Without consistency, even minor procedural variation can compromise your study’s outcomes — or result in significant rework.

The PRA Advantage: Onsite Expertise

When you partner with PRA, you gain access to a team of highly trained, experienced preclinical surgeons who perform bile duct cannulations at your facility, using validated SOPs and best practices. This model delivers multiple key benefits:

✅   No animal shipping – reduces stress and improves recovery

✅   Faster study starts – avoid transport and acclimation delays

✅   Higher success rates – thanks to surgical consistency and expert care

✅   Flexible study design – including dual cannulation, infusion models, and long-term bile collection

We can bring everything you need — equipment, protocols, staff, and quality assurance — so you can focus on your science, not logistics.

Applications We Support

PRA provides bile duct cannulation models for a variety of research areas, including:

– Drug metabolism and excretion

– Hepatobiliary disease models

– Toxicokinetics and safety testing

– Environmental toxicology

– Pre-IND submission studies

Start Strong. Stay Consistent.

At PRA, we believe precision drives progress. Our rodent bile duct models are designed to give you a reliable, high-quality platform for generating regulatory-grade data — all while prioritizing animal welfare and reducing operational overhead.

📩   Ready to bring bile duct surgery onsite?

Visit www.prasurgical.com or contact us to learn more.

Preclinical Research Associates

We ship the surgeon, not the animal.

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