Introduction

In preclinical research, obtaining accurate, real-time physiological data is critical for evaluating the safety and efficacy of new therapeutics. One technology that continues to transform the quality and scope of preclinical studies is telemetry. At PRA, we utilize telemetry across a wide range of species—from rodents to non-human primates—to collect continuous, high-quality data while minimizing stress and improving animal welfare.

What is Telemetry?

Telemetry involves the use of surgically implanted or external wireless devices that collect and transmit physiological data from conscious, freely moving animals. These implants allow researchers to monitor multiple parameters without the need for frequent handling or restraint, reducing variability and improving the translational value of preclinical studies.

Key Benefits of Telemetry in Preclinical Studies

Continuous Real-Time Data Collection
Telemetry enables continuous monitoring of physiological parameters over extended periods, providing a more complete understanding of a drug’s effects, including circadian patterns and subtle, transient events that traditional spot sampling might miss.

Reduction in Animal Stress
By eliminating the need for restraint, anesthesia, or repeated handling, telemetry allows animals to remain in their natural state during data collection. This leads to more accurate results and supports 3Rs (Replacement, Reduction, and Refinement) compliance.

Enhanced Data Quality and Consistency
With fewer external factors influencing measurements, telemetry produces more reliable, reproducible data, reducing study variability and increasing statistical power.

Support for Complex Study Designs
Telemetry allows simultaneous collection of multiple endpoints, making it ideal for dose-response studies, cardiovascular safety evaluations, toxicology assessments, and chronic administration models.

Physiological Parameters Collected via Telemetry

The versatility of telemetry systems enables the collection of a broad array of physiological endpoints, including:

  • Cardiovascular Function

    • Heart rate (HR)

    • Blood pressure (systolic, diastolic, mean arterial pressure)

    • Electrocardiogram (ECG)

    • QT interval monitoring

  • Neurological Function

    • EEG (electroencephalogram)

    • EMG (electromyography)

    • Seizure activity

    • Sleep studies

  • Respiratory Function

    • Respiratory rate

    • Tidal volume

    • Oxygen saturation

  • Temperature Regulation

    • Core body temperature

  • Activity & Behavioral Monitoring

    • Locomotor activity

    • Posture

    • Circadian rhythms

This breadth of data allows researchers to better understand the pharmacological and toxicological profiles of new compounds in real-world, translational conditions.

Species We Support

At PRA, we offer telemetry surgical and monitoring services in a wide range of species, including:

  • Mice

  • Rats

  • Guinea pigs

  • Canines

  • Non-Human Primates (NHPs)

Each species requires specialized surgical skill and post-operative care, and our expert surgical team is fully trained and experienced in performing these procedures under strict IACUC-compliant protocols.

Applications of Telemetry in Drug Development

Telemetry is widely used in:

  • Cardiovascular safety pharmacology (ICH S7A/S7B studies)

  • CNS drug development

  • Chronic toxicology studies

  • QT prolongation studies

  • Respiratory safety assessments

  • Translational biomarker development

With growing regulatory expectations for comprehensive safety and efficacy data, telemetry provides an efficient and highly informative approach to support decision-making in both early discovery and IND-enabling studies.

Telemetry has become a cornerstone technology in preclinical research, providing unparalleled data quality while improving animal welfare. At PRA, we are proud to offer full-service telemetry capabilities that help our clients generate meaningful, translatable data to advance their drug development programs.

Interested in learning how PRA’s telemetry services can enhance your next study? Contact us today to discuss your project.

www.prasurgical.com

info@prasurgical.com