Why Use a Rodent MI Model?

Rodent MI models, particularly in rats and mice, are widely used to study the pathophysiology of heart disease, evaluate cardioprotective therapies, and test regenerative medicine approaches. Surgical induction of MI, typically through left anterior descending (LAD) coronary artery ligation, simulates the conditions of a human heart attack and enables:

– Investigation of infarct size and remodeling
– Assessment of post-MI therapies
– Longitudinal evaluation of cardiac function
– Gene and cell therapy testing
– Histopathological and biomarker analysis

With the right technique and expertise, rodent MI models offer high translational value with excellent control over injury size and location.

Challenges of Myocardial Infarction Surgery

Myocardial infarction induction in rodents is a technically demanding procedure that requires:

– Microsurgical precision
– Ventilation and anesthesia management
– Proper post-operative monitoring and care
– Strict adherence to animal welfare and IACUC guidelines

Without a highly skilled surgical team, results can vary significantly, compromising both data integrity and animal welfare.

The PRA Advantage

At PRA, our onsite surgical team brings extensive experience in performing rodent MI surgeries at your facility. We ensure consistency, compliance, and care at every step:

– Experienced surgeons trained in LAD ligation and thoracic techniques
– Consistent infarct creation, minimizing experimental variability
– Real-time monitoring, ensuring surgical accuracy and animal safety
– Support for both acute and chronic MI studies
– Post-operative care protocols tailored to your study design
– Integration with telemetry, drug delivery systems, and functional imaging

By bringing our expertise to your site, we eliminate the need to ship animals, reduce stress-related variables, and give your team full transparency and control.

Applications We Support

Our myocardial infarction model services are ideal for:

– Cardioprotective drug screening
– Stem cell and gene therapy trials
– Post-MI remodeling and fibrosis studies
– Electrophysiology research
– Pharmacokinetics and pharmacodynamics in cardiac tissue

Partner with PRA for Cardiac Research Success

Whether you’re exploring new heart failure therapies or testing novel delivery systems, PRA provides the surgical precision and scientific support you need. Our mission is to help you generate clean, reliable cardiovascular data — right from your own lab.

📩 Contact us today to learn how PRA can support your next preclinical cardiac study.

Preclinical Research Associates
Expert Surgical Services. Ethical Standards. Reliable Results.

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